Abnormal activation of your Wnt/β-catenin pathway promotes CSC development and therefore causes the deterioration and metastasis of most cancers [129]. For instance, irregular activation of Wnt signaling disrupted the conventional development and differentiation of colonic crypt stem cells, leading to a colorectal CSC phenotype by upregulating expression of target genes https://derekr999qja0.goabroadblog.com/profile