The identified affect of those PTMs on ATXN2’s operate and SCA2 pathogenesis stays minimal. In other polyQ diseases, numerous research proposed that proteolytic cleavage of polyQ proteins could Engage in a vital position in pathogenesis [36, 45]. Aligned using this notion, the presence of the enriched forty two kDa fragment inside https://johnathanezqiy.azzablog.com/28426819/new-step-by-step-map-for-ataxin-8-protein