Environmental or self-antigens and homotypic interactions trigger BCR and Toll-like receptor (TLR) signaling, amplifying the response of CLL cells to other signals with the microenvironment and increasing the activation of anti-apoptotic and proliferation pathways.31,32 Genomic studies have recognized recurrent mutations in genes regulating tumor mobile-microenvironment interactions, ... https://milesn530jsz8.oneworldwiki.com/user