A comprehensive literature critique of scientific studies in between 1995 and 2018 was done using the electronic databases PubMed and EBSCO Host. Searches had been performed making use of the next terms: complete knee arthroplasty (TKA); cyclooxygenase-2 inhibitors; bracing; physical therapy; weight-loss; knee; treatment; therapeutics; OA; intra-articular injection; hyaluronic acid; https://www.theorthopaedicandpainpractice.com/non-surgical-treatments-for-knee-joint-pain/