Pentobarbital will decrease the level or effect of hydrocortisone by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Monitor. pentobarbital will decrease the level or effect of diclofenac by affecting hepatic enzyme CYP2C9/10 metabolism. Minor/Significance Unknown. pentobarbital will decrease the level or effect of buprenorphine buccal by affecting hepatic/intestina... https://gatherbookmarks.com/story21169989/the-ultimate-guide-to-pentobarbital-de-sodium